Vulnerability-Lookup

GHSA-5P87-Q7F6-JF7X

Vulnerability from github – Published: 2026-08-05 21:31 – Updated: 2026-08-05 21:31

Details

The affected

Thermo Fisher Applied Biosystems Genetic Analyzers are vulnerable because .fsa/.hid output files can be edited. An attacker could tamper with these files, altering DNA data and resulting in inaccurate DNA test outcomes.

Severity

8.4 (High)


                  
                    CVSS:3.1/AV:L/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H

8.3 (High)


                  
                    CVSS:4.0/AV:L/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:H/SC:N/SI:H/SA:N

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JSON

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{
  "affected": [],
  "aliases": [
    "CVE-2026-17583"
  ],
  "database_specific": {
    "cwe_ids": [
      "CWE-353"
    ],
    "github_reviewed": false,
    "github_reviewed_at": null,
    "nvd_published_at": "2026-08-05T21:16:57Z",
    "severity": "HIGH"
  },
  "details": "The affected\n\nThermo Fisher Applied Biosystems Genetic Analyzers are\u00a0vulnerable because .fsa/.hid output files can be edited. An attacker could tamper with these files, altering DNA data and resulting in inaccurate DNA test outcomes.",
  "id": "GHSA-5p87-q7f6-jf7x",
  "modified": "2026-08-05T21:31:39Z",
  "published": "2026-08-05T21:31:39Z",
  "references": [
    {
      "type": "ADVISORY",
      "url": "https://nvd.nist.gov/vuln/detail/CVE-2026-17583"
    },
    {
      "type": "WEB",
      "url": "https://documents.thermofisher.com/TFS-Assets/CORP/Product-Guides/fsa_hid_bulletin.pdf"
    },
    {
      "type": "WEB",
      "url": "https://www.cisa.gov/news-events/ics-medical-advisories/icsma-26-216-01"
    },
    {
      "type": "WEB",
      "url": "https://www.cve.org/CVERecord?id=CVE-2026-17583"
    }
  ],
  "schema_version": "1.4.0",
  "severity": [
    {
      "score": "CVSS:3.1/AV:L/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H",
      "type": "CVSS_V3"
    },
    {
      "score": "CVSS:4.0/AV:L/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:H/SC:N/SI:H/SA:N/E:X/CR:X/IR:X/AR:X/MAV:X/MAC:X/MAT:X/MPR:X/MUI:X/MVC:X/MVI:X/MVA:X/MSC:X/MSI:X/MSA:X/S:X/AU:X/R:X/V:X/RE:X/U:X",
      "type": "CVSS_V4"
    }
  ]
}

CVE-2026-17583 (GCVE-0-2026-17583)

Vulnerability from cvelistv5 – Published: 2026-08-05 20:23 – Updated: 2026-08-06 13:34

Title

Thermo Fisher Applied Biosystems Genetic Analyzers Missing Support for Integrity Check

Summary

The affected Thermo Fisher Applied Biosystems Genetic Analyzers are vulnerable because .fsa/.hid output files can be edited. An attacker could tamper with these files, altering DNA data and resulting in inaccurate DNA test outcomes.

Severity

8.4 (High)


                        
                          CVSS:3.1/AV:L/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H

8.3 (High)


                        
                          CVSS:4.0/AV:L/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:H/SC:N/SI:H/SA:N

SSVC

Exploitation: none Automatable: no Technical Impact: total

CISA Coordinator (v2.0.3)

CWE

CWE-353

Assigner

icscert

References

3 references

URL	Tags
https://documents.thermofisher.com/TFS-Assets/COR…
https://www.cisa.gov/news-events/ics-medical-advi…
https://www.cve.org/CVERecord?id=CVE-2026-17583

Impacted products

8 products

Vendor	Product	Version
Thermo Fisher	Applied Biosystems 3500/3500xL Series Data Collection Software	Affected: 0 , ≤ 4.0.2 (custom)
Thermo Fisher	Applied Biosystems 3730/3730xL Series Data Collection Software	Affected: 0 , ≤ 5.0.2 (custom)
Thermo Fisher	Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software	Affected: 0 , ≤ 1.2.5 (custom)
Thermo Fisher	Applied Biosystems SeqStudio Flex Series Instrument Software	Affected: 0 , ≤ 1.2.0 (custom)
Thermo Fisher	Applied Biosystems GeneMapper ID-X Software	Affected: 0 , ≤ 1.7.3 (custom)
Thermo Fisher	Applied Biosystems 3130 Series Data Collection Software	Affected: 0 , ≤ 4.1 (custom)
Thermo Fisher	ABI PRISM 3100/3100-Avant Data Collection Software	Affected: 0 , ≤ 2.0 (custom)
Thermo Fisher	ABI PRISM 310 Data Collection Software	Affected: 0 , ≤ 3.1 (custom)

Credits

Nathaniel Adams, Laura Gaydosh-Combs, and Kevin Dyer reported this vulnerability to CISA.

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JSON

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{
  "containers": {
    "adp": [
      {
        "metrics": [
          {
            "other": {
              "content": {
                "id": "CVE-2026-17583",
                "options": [
                  {
                    "Exploitation": "none"
                  },
                  {
                    "Automatable": "no"
                  },
                  {
                    "Technical Impact": "total"
                  }
                ],
                "role": "CISA Coordinator",
                "timestamp": "2026-08-06T13:34:47.788856Z",
                "version": "2.0.3"
              },
              "type": "ssvc"
            }
          }
        ],
        "providerMetadata": {
          "dateUpdated": "2026-08-06T13:34:57.240Z",
          "orgId": "134c704f-9b21-4f2e-91b3-4a467353bcc0",
          "shortName": "CISA-ADP"
        },
        "title": "CISA ADP Vulnrichment"
      }
    ],
    "cna": {
      "affected": [
        {
          "defaultStatus": "unaffected",
          "product": "Applied Biosystems 3500/3500xL Series Data Collection Software",
          "vendor": "Thermo Fisher",
          "versions": [
            {
              "lessThanOrEqual": "4.0.2",
              "status": "affected",
              "version": "0",
              "versionType": "custom"
            }
          ]
        },
        {
          "defaultStatus": "unaffected",
          "product": "Applied Biosystems 3730/3730xL Series Data Collection Software",
          "vendor": "Thermo Fisher",
          "versions": [
            {
              "lessThanOrEqual": "5.0.2",
              "status": "affected",
              "version": "0",
              "versionType": "custom"
            }
          ]
        },
        {
          "defaultStatus": "unaffected",
          "product": "Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software",
          "vendor": "Thermo Fisher",
          "versions": [
            {
              "lessThanOrEqual": "1.2.5",
              "status": "affected",
              "version": "0",
              "versionType": "custom"
            }
          ]
        },
        {
          "defaultStatus": "unaffected",
          "product": "Applied Biosystems SeqStudio Flex Series Instrument Software",
          "vendor": "Thermo Fisher",
          "versions": [
            {
              "lessThanOrEqual": "1.2.0",
              "status": "affected",
              "version": "0",
              "versionType": "custom"
            }
          ]
        },
        {
          "defaultStatus": "unaffected",
          "product": "Applied Biosystems GeneMapper ID-X Software",
          "vendor": "Thermo Fisher",
          "versions": [
            {
              "lessThanOrEqual": "1.7.3",
              "status": "affected",
              "version": "0",
              "versionType": "custom"
            }
          ]
        },
        {
          "defaultStatus": "unaffected",
          "product": "Applied Biosystems 3130 Series Data Collection Software",
          "vendor": "Thermo Fisher",
          "versions": [
            {
              "lessThanOrEqual": "4.1",
              "status": "affected",
              "version": "0",
              "versionType": "custom"
            }
          ]
        },
        {
          "defaultStatus": "unaffected",
          "product": "ABI PRISM 3100/3100-Avant Data Collection Software",
          "vendor": "Thermo Fisher",
          "versions": [
            {
              "lessThanOrEqual": "2.0",
              "status": "affected",
              "version": "0",
              "versionType": "custom"
            }
          ]
        },
        {
          "defaultStatus": "unaffected",
          "product": "ABI PRISM 310 Data Collection Software",
          "vendor": "Thermo Fisher",
          "versions": [
            {
              "lessThanOrEqual": "3.1",
              "status": "affected",
              "version": "0",
              "versionType": "custom"
            }
          ]
        }
      ],
      "credits": [
        {
          "lang": "en",
          "type": "finder",
          "value": "Nathaniel Adams, Laura Gaydosh-Combs, and Kevin Dyer reported this vulnerability to CISA."
        }
      ],
      "descriptions": [
        {
          "lang": "en",
          "supportingMedia": [
            {
              "base64": false,
              "type": "text/html",
              "value": "\u003cspan\u003eThe affected\u003c/span\u003e\n\nThermo Fisher Applied Biosystems Genetic Analyzers are\u003cspan\u003e\u0026nbsp;vulnerable because .fsa/.hid output files can be edited. An attacker could tamper with these files, altering DNA data and resulting in inaccurate DNA test outcomes.\u003c/span\u003e"
            }
          ],
          "value": "The affected\n\nThermo Fisher Applied Biosystems Genetic Analyzers are\u00a0vulnerable because .fsa/.hid output files can be edited. An attacker could tamper with these files, altering DNA data and resulting in inaccurate DNA test outcomes."
        }
      ],
      "metrics": [
        {
          "cvssV3_1": {
            "attackComplexity": "LOW",
            "attackVector": "LOCAL",
            "availabilityImpact": "HIGH",
            "baseScore": 8.4,
            "baseSeverity": "HIGH",
            "confidentialityImpact": "HIGH",
            "integrityImpact": "HIGH",
            "privilegesRequired": "NONE",
            "scope": "UNCHANGED",
            "userInteraction": "NONE",
            "vectorString": "CVSS:3.1/AV:L/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H",
            "version": "3.1"
          },
          "format": "CVSS",
          "scenarios": [
            {
              "lang": "en",
              "value": "GENERAL"
            }
          ]
        },
        {
          "cvssV4_0": {
            "Automatable": "NOT_DEFINED",
            "Recovery": "NOT_DEFINED",
            "Safety": "NOT_DEFINED",
            "attackComplexity": "LOW",
            "attackRequirements": "NONE",
            "attackVector": "LOCAL",
            "baseScore": 8.3,
            "baseSeverity": "HIGH",
            "exploitMaturity": "NOT_DEFINED",
            "privilegesRequired": "NONE",
            "providerUrgency": "NOT_DEFINED",
            "subAvailabilityImpact": "NONE",
            "subConfidentialityImpact": "NONE",
            "subIntegrityImpact": "HIGH",
            "userInteraction": "NONE",
            "valueDensity": "NOT_DEFINED",
            "vectorString": "CVSS:4.0/AV:L/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:H/SC:N/SI:H/SA:N",
            "version": "4.0",
            "vulnAvailabilityImpact": "HIGH",
            "vulnConfidentialityImpact": "NONE",
            "vulnIntegrityImpact": "HIGH",
            "vulnerabilityResponseEffort": "NOT_DEFINED"
          },
          "format": "CVSS",
          "scenarios": [
            {
              "lang": "en",
              "value": "GENERAL"
            }
          ]
        }
      ],
      "problemTypes": [
        {
          "descriptions": [
            {
              "cweId": "CWE-353",
              "description": "CWE-353",
              "lang": "en",
              "type": "CWE"
            }
          ]
        }
      ],
      "providerMetadata": {
        "dateUpdated": "2026-08-05T20:23:32.890Z",
        "orgId": "7d14cffa-0d7d-4270-9dc0-52cabd5a23a6",
        "shortName": "icscert"
      },
      "references": [
        {
          "url": "https://documents.thermofisher.com/TFS-Assets/CORP/Product-Guides/fsa_hid_bulletin.pdf"
        },
        {
          "url": "https://www.cisa.gov/news-events/ics-medical-advisories/icsma-26-216-01"
        },
        {
          "url": "https://www.cve.org/CVERecord?id=CVE-2026-17583"
        }
      ],
      "solutions": [
        {
          "lang": "en",
          "supportingMedia": [
            {
              "base64": false,
              "type": "text/html",
              "value": "\u003cp\u003eThermo Fisher has developed security updates to address the vulnerability. The security updates implement the use of digital signatures on the instrument software that adds an extralayer of protection. Moving forward, this will help users verify that data files have not been modified.\u003c/p\u003e\u003cp\u003eApplied Biosystems 3500/3500xL Series Data Collection Software: Update to version 4.0.3\u003cbr\u003e\u003ca href=\"https://downloads.thermofisher.com/3500_DCS_v4.0.3_Patch/v4.0.3_Patch_Installer.exe\"\u003ehttps://downloads.thermofisher.com/3500_DCS_v4.0.3_Patch/v4.0.3_Patch_Installer.exe\u003c/a\u003e\u003c/p\u003e\u003cp\u003eApplied Biosystems 3730/3730xL Series Data Collection Software: Update to version 5.0.3\u003cbr\u003e\u003ca href=\"https://downloads.thermofisher.com/3730xl_UDC_v5.0.3_Patch/3730xl_UDC_v5.0.3_Patch.exe\"\u003ehttps://downloads.thermofisher.com/3730xl_UDC_v5.0.3_Patch/3730xl_UDC_v5.0.3_Patch.exe\u003c/a\u003e\u003c/p\u003e\u003cp\u003eApplied Biosystems SeqStudio Genetic Analyzer Data Collection Software: Update to version 1.2.6\u003cbr\u003e\u003ca href=\"https://downloads.thermofisher.com/SeqStudio/1.2.6/SeqStudio-1.2.6.abpkg\"\u003ehttps://downloads.thermofisher.com/SeqStudio/1.2.6/SeqStudio-1.2.6.abpkg\u003c/a\u003e\u003c/p\u003e\u003cp\u003eApplied Biosystems SeqStudio Flex Series Instrument Software: Update to version 1.2.1\u003cbr\u003e\u003ca href=\"https://downloads.thermofisher.com/SeqStudioFlex/1.2.1/SeqStudioFlex-1.2.1.abpkg\"\u003ehttps://downloads.thermofisher.com/SeqStudioFlex/1.2.1/SeqStudioFlex-1.2.1.abpkg\u003c/a\u003e\u003c/p\u003e\u003cp\u003eApplied Biosystems GeneMapper ID-X Software: Update to version 1.7.4\u003cbr\u003e\u003ca href=\"https://downloads.thermofisher.com/GeneMapperID-Xv1.7.4_Patch/GMIDX_v1.7.4_Patch.exe\"\u003ehttps://downloads.thermofisher.com/GeneMapperID-Xv1.7.4_Patch/GMIDX_v1.7.4_Patch.exe\u003c/a\u003e\u003c/p\u003e"
            }
          ],
          "value": "Thermo Fisher has developed security updates to address the vulnerability. The security updates implement the use of digital signatures on the instrument software that adds an extralayer of protection. Moving forward, this will help users verify that data files have not been modified.\n\n\n\nApplied Biosystems 3500/3500xL Series Data Collection Software: Update to version 4.0.3\n https://downloads.thermofisher.com/3500_DCS_v4.0.3_Patch/v4.0.3_Patch_Installer.exe \n\n\n\nApplied Biosystems 3730/3730xL Series Data Collection Software: Update to version 5.0.3\n https://downloads.thermofisher.com/3730xl_UDC_v5.0.3_Patch/3730xl_UDC_v5.0.3_Patch.exe \n\n\n\nApplied Biosystems SeqStudio Genetic Analyzer Data Collection Software: Update to version 1.2.6\n https://downloads.thermofisher.com/SeqStudio/1.2.6/SeqStudio-1.2.6.abpkg \n\n\n\nApplied Biosystems SeqStudio Flex Series Instrument Software: Update to version 1.2.1\n https://downloads.thermofisher.com/SeqStudioFlex/1.2.1/SeqStudioFlex-1.2.1.abpkg \n\n\n\nApplied Biosystems GeneMapper ID-X Software: Update to version 1.7.4\n https://downloads.thermofisher.com/GeneMapperID-Xv1.7.4_Patch/GMIDX_v1.7.4_Patch.exe"
        }
      ],
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        "advisory": "ICSMA-26-216-01",
        "discovery": "EXTERNAL"
      },
      "title": "Thermo Fisher Applied Biosystems Genetic Analyzers Missing Support for Integrity Check",
      "workarounds": [
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              "type": "text/html",
              "value": "\u003cp\u003eApplied Biosystems 3130 Series Data Collection Software: Product is End of Life (EoL), no update provided\u003cbr\u003eABI PRISM 3100/3100-Avant Data Collection Software: Product is End of Life (EoL), no update provided\u003cbr\u003eABI PRISM 310 Data Collection Software: Product is End of Life (EoL), no update provided\u003c/p\u003e\u003cp\u003eFor users who are unable to immediately implement all applicable security updates, Thermo Fisher Scientific recommends implementing the following interim mitigation measures until the applicable updates have been installed:\u0026nbsp;\u003c/p\u003e\u003cul\u003e\u003cli\u003eMaintain a secure chain of custody for files generated by the HID instrumentation throughout the analysis workflow.\u003c/li\u003e\u003cli\u003eStore generated files on encrypted, password-protected storage media (for example, encrypted USB drives or encrypted hard drives).\u003c/li\u003e\u003cli\u003eRestrict access to generated files to authorized personnel in accordance with your laboratory\u0027s access control policies.\u003c/li\u003e\u003cli\u003eApply the principle of least privilege by limiting user permissions on systems operating the HID instrumentation or hosting associated data analysis and secondary analysis software.\u003c/li\u003e\u003cli\u003eLeverage firewall rules and network access control lists (NACLs) to restrict internet connectivity to only trusted sources.\u003c/li\u003e\u003c/ul\u003e\u003cp\u003eFor more information, refer to Thermo Fisher\u0027s security bulletin.\u003cbr\u003e\u003ca href=\"https://documents.thermofisher.com/TFS-Assets/CORP/Product-Guides/fsa_hid_bulletin.pdf\"\u003ehttps://documents.thermofisher.com/TFS-Assets/CORP/Product-Guides/fsa_hid_bulletin.pdf\u003c/a\u003e\u003c/p\u003e"
            }
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          "value": "Applied Biosystems 3130 Series Data Collection Software: Product is End of Life (EoL), no update provided\nABI PRISM 3100/3100-Avant Data Collection Software: Product is End of Life (EoL), no update provided\nABI PRISM 310 Data Collection Software: Product is End of Life (EoL), no update provided\n\n\n\nFor users who are unable to immediately implement all applicable security updates, Thermo Fisher Scientific recommends implementing the following interim mitigation measures until the applicable updates have been installed:\u00a0\n\n  *  Maintain a secure chain of custody for files generated by the HID instrumentation throughout the analysis workflow.\n  *  Store generated files on encrypted, password-protected storage media (for example, encrypted USB drives or encrypted hard drives).\n  *  Restrict access to generated files to authorized personnel in accordance with your laboratory\u0027s access control policies.\n  *  Apply the principle of least privilege by limiting user permissions on systems operating the HID instrumentation or hosting associated data analysis and secondary analysis software.\n  *  Leverage firewall rules and network access control lists (NACLs) to restrict internet connectivity to only trusted sources.\n\n\n\n\nFor more information, refer to Thermo Fisher\u0027s security bulletin.\n https://documents.thermofisher.com/TFS-Assets/CORP/Product-Guides/fsa_hid_bulletin.pdf"
        }
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  "cveMetadata": {
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    "assignerShortName": "icscert",
    "cveId": "CVE-2026-17583",
    "datePublished": "2026-08-05T20:23:32.890Z",
    "dateReserved": "2026-07-27T15:53:40.951Z",
    "dateUpdated": "2026-08-06T13:34:57.240Z",
    "state": "PUBLISHED"
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}

Sightings

Author	Source	Type	Date	Other

Nomenclature

Seen: The vulnerability was mentioned, discussed, or observed by the user.
Confirmed: The vulnerability has been validated from an analyst's perspective.
Published Proof of Concept: A public proof of concept is available for this vulnerability.
Exploited: The vulnerability was observed as exploited by the user who reported the sighting.
Patched: The vulnerability was observed as successfully patched by the user who reported the sighting.
Not exploited: The vulnerability was not observed as exploited by the user who reported the sighting.
Not confirmed: The user expressed doubt about the validity of the vulnerability.
Not patched: The vulnerability was not observed as successfully patched by the user who reported the sighting.

Detection rules are retrieved from Rulezet.

The MITRE ATT&CK techniques below are AI-generated suggestions, inferred from the description of the vulnerability by the CIRCL/vulnerability-attack-technique-classification-roberta-base model, served locally by ML-Gateway. They have not been verified by an analyst and are provided for guidance only.

Action not permitted

GHSA-5P87-Q7F6-JF7X

CVE-2026-17583 (GCVE-0-2026-17583)

Tags

Sightings

Nomenclature